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  Indian J Med Microbiol
 

Figure 1: Histopathological findings of ciprofloxacin on the testis. A: The control group: 1) Normal seminiferous tubules in rabbit, 2) Sertoli cell, 3) Spermatogonium cell, 4) Primary spermatocyte, 5) Round spermatid, 6) Rod spermatid, 7) Spermatozoa (H & E, X400). B: Ciprofloxacin-treated group: B1) Severe degeneration of germinal epithelium, sloughing of epithelial cells into lumen (arrow) and remained Sertoli cell with a marked nucleolus (arrowhead) (H & E, X400); B2): Degeneration of the germ cells and presence of multinucleated cells in seminal lumen (arrow) (H & E, X400); B3): Wrinkled and collapsed tubules due to severe degeneration of the germ cell lines as well as hemorrhage (arrows) between tubules (H & E, X100). C: Ciprofloxacin-treated group for 56 days following last ciprofloxacin. Mild degenerative changes as vacuolation and increasing space (arrows) in germinal epithelium of seminiferous tubules (H & E, X400).

Figure 1: Histopathological findings of ciprofloxacin on the testis. A: The control group: 1) Normal seminiferous tubules in rabbit, 2) Sertoli cell, 3) Spermatogonium cell, 4) Primary spermatocyte, 5) Round spermatid, 6) Rod spermatid, 7) Spermatozoa (H & E, X400). B: Ciprofloxacin-treated group: B1) Severe degeneration of germinal epithelium, sloughing of epithelial cells into lumen (arrow) and remained Sertoli cell with a marked nucleolus (arrowhead) (H & E, X400); B2): Degeneration of the germ cells and presence of multinucleated cells in seminal lumen (arrow) (H & E, <sup>X</sup>400); B3): Wrinkled and collapsed tubules due to severe degeneration of the germ cell lines as well as hemorrhage (arrows) between tubules (H & E, X100). C: Ciprofloxacin-treated group for 56 days following last ciprofloxacin. Mild degenerative changes as vacuolation and increasing space (arrows) in germinal epithelium of seminiferous tubules (H & E, X400).