• Users Online: 458
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 3  |  Page : 136-138

Prediction of protein structure of novel protein (116 kDa) from human sperm membrane


1 Laboratory of Molecular Biology, Department of Biology, State University of Malang, Malang, East Java, Indonesia
2 Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia

Correspondence Address:
Umie Lestari
Department of Biology, Faculty of Mathematics and Natural Sciences, State University of Malang, Malang, East Java
Indonesia
Widodo
Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University. Jl. Veteran, Malang
Indonesia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.233575

Rights and Permissions

Objective: To predict the protein similarity, biological function and structure of 116 kDa protein that was isolated from human sperm membrane of acrosome by using in silico. Methods: Predictions for 116 kDa protein similarity was done through comparative analysis of its isoelectric point (pI) and molecular weight to the UniProtKB/TrEMBL protein database. The three-dimensional structure of the protein was built using SWISS-MODEL. Results: The 116 kDa protein with pI 4.4 was expected to have similarities with CDH23 proteins that had pI 4.38, thus they likely had similar physical and biochemical properties. The predicted protein had an extracellular N-terminal that likely acted as a receptor, and showed cell recognition characteristic, playing a role in fertilization. Conclusions: The 116 kDa protein isolated from acrosome membrane has similarity on its biophysical character to the CDH23.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed680    
    Printed35    
    Emailed0    
    PDF Downloaded91    
    Comments [Add]    

Recommend this journal