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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 3  |  Page : 129-135

Antiandrogenic activity of Calotropis procera latex in rats


1 College of Graduate Studies, University of Gezira, Sudan; Department of Physiology, Faculty of Medicine, Najran University, Saudi Arabia
2 Department of Applied Medical Sciences, Community College, Najran University, Saudi Arabia

Correspondence Address:
Abdelgader Binyamen Abdelgader
College of Graduate Studies, University of Gezira, Sudan; Department of Physiology, Faculty of Medicine, Najran University, Saudi Arabia

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.233574

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Objective: To determine the effects of Calotropis procera latex on pubertal traits of immature male Wistar rats. Methods: A total of 30 immature male Wistar rats aged 3 weeks old were grouped randomly into 5 groups: group A (control group) was offered distilled water as a placebo; group B was daily oral dosed with suspension of Calotropis procera latex at a dose rate of 5 mg/kg BW, group C 10 mg/kg BW; group D 15 mg/kg BW and group E 20 mg/ kg BW. The rats were weighed daily to adjust the dose and record the BW changes, and the treatment continued for 4 weeks; thereafter, rats were sacrificed. Serum samples (n=30) were collected from all rats and kept frozen until assayed for reproductive hormones. Furthermore, the testes and epididymae were weighed; epididymal sperms were counted; sperm motility & abnormality were estimated; and histopathological sections of the testes were prepared. Results: The results of this study showed that oral dosing of immature male rats with Calotropis procera latex at doses rate 10 mg/kg BW significantly (P<0.05) reduced the growth rate, BW, testicular & epididymal weights, the level of most of reproductive hormones as well as the sperm traits examined; however, it significantly (P<0.05) augmented the abnormalities of spermatozoa and the seminiferous epithelium. Conclusions: Latex of Calotropis procera contains substances that have anti-androgenic activities and/or endocrine disrupting effects. If these substances are purified and identified, they can be used as male contraceptives.


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