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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 3  |  Page : 117-122

Effect of alcohol infusion of Cissus populnea root on testicular function and serum hormone of male Wistar rats


1 Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, PMB 1001, Omu-Aran, Kwara State, Nigeria
2 Obstetrics and Gynaecology Unit, Federal Teaching Hospital, PMB 201, Ido-Ekiti, Ekiti State, Nigeria

Correspondence Address:
Tomilola D Olaolu
Biochemistry Unit, Department of Biological Sciences, College of Science and Engineering, Landmark University, PMB 1001, Omu-Aran, Kwara State
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.233572

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Objective: To examine the effect of Cissus populnea root on testicular function of male Wistar rats. Methods: Twenty albino male Wistar rats [(100.0 ±25.5) g] were selected into four groups randomly. The control group were administered 0.20 mL of distilled water while the other groups received 0.05 mL, 0.10 mL, and 0.20 mL/kg body weight of ethanol infusion. Oral administration was done using oropharyngeal cannula once daily for 14 days. Animals were thereafter sacrificed on day 15. Data obtained from this study were analysed using one-way analysis of variance (ANOVA) with multiple comparisons, post-hoc Tukey HSD was subsequently used and values at P<0.05 were considered statistically significant. Results: There were significant increases in serum testosterone, testes-body weight ratio, luteinising hormone and follicle stimulating hormone, respectively, compared with those in control group. Similarly, increase in acid phosphatase, alkaline phosphatase, protein, glycogen and cholesterol levels were more significant compared with those in control group. Conclusions: The findings of this study reveals enhanced secretions of the sex hormones and other indices at 0.05 mL/kg body weight administration of Cissus populnea root ethanol infusion. However, dosages exceeding 0.05 mL/kg body weight gradually depletes the level of reproductive indices assayed for in this current study. Therefore, caution must be taken when consuming ethanol infusion of Cissus populnea root above the dosages used in this current study.


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