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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 2  |  Page : 56-61

Homeostatic relevance of vitamin D in maintaining male fertility in human: Down–regulation of oxidative stress and up-regulation of anti-oxidative defense and steroidal hormones


1 Institute of Molecular Biology and Biotechnology, The University of Lahore, Raiwind Road 55150, Lahore, Pakistan
2 Department of Biochemistry, Akhtar Saeed Medical and Dental Collage, Lahore, Pakistan
3 Department of Physiology, Nishtar Medical University, 66000, Multan, Pakistan
4 Department of Biochemistry, University of Agriculture, Faisalabad, 38040, Pakistan
5 Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia
6 Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia

Correspondence Address:
Arif Malik
Institute of Molecular Biology and Biotechnology, The University of Lahore, Raiwind Road 55150, Lahore
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2305-0500.228014

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Objective: To evaluate correlation between the levels of vitamin D and male infertility as well as to determine the efficacy of vitamin D in improving the male fertility by up-regulating the levels of testosterone and spermatogenesis. Methods: In the present study, 130 male patients (aged 25-70 years) having fertility defects were screened and 145 healthy individuals were taken as control. All human subjects were screened for 4-hydroxynonenal, isoprostane-F2α, 8-hydroxy-2'-deoxyguanosine, vitamin D, luteinizing hormone, follicle stimulating hormone, testosterones, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and nitric oxide. Results: The screening analysis revealed that the levels of luteinizing hormone, follicle stimulating hormone, and testosterone were lower in male infertile subjects compared to healthy subjects. Similarly, the levels of vitamin D [(17.17 ± 2.30) ng/mL] and calcium[(6.29 ± 0.31) mg/dL] were significantly lower in infertile groups compared to the normal healthy groups. Moreover, the study revealed that the levels of superoxide dismutase, catalase, and glutathione peroxidase were significantly higher in healthy subjects compared to the infertile subjects. Conclusions: Vitamin D exhibits strong relevance to male fertility by maintaining the levels of sex hormones (luteinizing hormone, follicle stimulating hormone, and testosterone), up-regulating the antioxidant defense (superoxide dismutase, catalase, and glutathione peroxidase), and down-regulating the oxidative stress (malondialdehyde, nitric oxide, and inducible nitric oxide synthase species).


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